Articles
Formulation and technology development for a synbiotic food supplement from Arctic plant raw materials for the prevention of dysbacteriosis
Authors:
Vladimir G. Popov, Victoria V. Aksentyeva, Elena Yu. Leonova
Abstract:
Intestinal microflora is considered a key determinant of human health. Secondary dysbiotic disorders require restoration of normal flora rather than eradication of opportunistic bacteria. Synbiotics based on Arctic plant polyphenols offer the most effective solutions for preventing dysbiosis. The aim of this article was to develop a synbiotic food supplement technology capable of restoring the microbiome using Arctic plant materials. The choice of plant materials was justified using DFT screening of polyphenols contained in lingonberry and russula leaves. Chlorogenic acid was found to possess the highest electron energy (–1297.14 Hartree), while gallic acid had the lowest value (–646.28 Hartree). The authors performed molecular docking with mucin-binding protein and β-galactosidase. The molecular interactions and their potential impact on probiotic adhesion and metabolism are interpreted. Arctic plant materials were selected based on a combination of functional properties (high antioxidant activity, antimicrobial action, prebiotic potential and thermal stability). The authors developed a scientifically proven formula for a synbiotic food supplement based on Arctic plant materials, including extracts of lingonberry and umbellate leaf biomass, freeze-dried arctic berries and cloudberries, and sprouted hulled oat concentrate. The quantitative ratio of the ingredients was determined using the simplex method. A technology for producing a synbiotic supplement in microcapsule form has been developed, including freeze-drying, mixing with probiotics, and microencapsulation. The practical significance of this research lies in the creation of an import-substituting, technologically feasible synbiotic supplement based on readily available Arctic raw materials from the Tyumen region.
Keywords:
dysbacteriosis; probiotic; prebiotic; synbiotic; arctic raw materials; polyphenols
For citation:
Popov V.G., Aksentyeva V.V., Leonova E.Yu. Formulation and technology development for a synbiotic food supplement from Arctic plant raw materials for the prevention of dysbacteriosis. Индустрия питания|Food Industry. 2026. Vol. 11, No. 3. Pp. 79–92. DOI: 10.29141/2500-1922-2026-11-3-8. EDN: TOWYIE.
