Designing personalized preventive diets for consumers with a genetic predisposition to bulimia nervosa
Authors:
Evgeniya E. Klein, Darya A. Velina, Igor A. Nikitin
Abstract:
This article explores the relevance and importance of non-drug prevention of bulimia nervosa using personalized nutrition strategies to ensure individual well-being of consumers and address socio-demographic concerns at the national level. The aim of the study is to design a preventive diet and develop a personalized nutrition strategy for carriers of SLC6A4, DRD2, and FTO gene polymorphisms, who have an increased predisposition to nervous bulimia. The authors propose a number of genetic polymorphisms that could be useful as markers of increased susceptibility to bulimia nervosa. Specifically, they note the important contribution of polymorphisms in genes involved in the serotonergic and dopaminergic systems, as well as the FTO gene, a known determinant of overeating tendencies. Nutrients have been identified whose biological activity helps reduce the negative impact of genetic factors on consumer eating behavior by regulating neurotransmitter synthesis and signaling, suppressing inflammation, increasing dopamine receptor concentrations in the brain, and other mechanisms with antidepressant properties. The authors developed and analyzed three personalized nutritional plans for the target consumer with given parameters in terms of effectiveness in the context of bulimia nervosa prevention. Elements of the nutritional strategy that help prevent negative eating behavior patterns are described, including recommendations on the frequency and duration of individual meals to manage eating behavior through hunger and satiety cues. Methods for increasing mindfulness regarding eating by focusing on food intake and eliminating distractions that contribute to overeating are proposed. The obtained results can be used as an effective preventive measure for bulimia nervosa to reduce the prevalence of the disease in the population.
Keywords:
genetic polymorphism; dopamine; bulimia nervosa; personalized nutrition; diet; prevention; eating disorders; serotonin; DRD2; FTO; SLC6A4
For citation:
Klein E.E., Velina D.A., Nikitin I.A. Designing personalized preventative diets for consumers with a genetic predisposition to bulimia nervosa. Индустрия питания|Food Industry. 2026. Vol. 11, No. 3. Pp. 5–14. DOI: 10.29141/2500-1922-2026-11-3-1. EDN: FKDGNJ.
